Glucocorticoids Inhibit Phospholipase A2
Glucocorticoids are a class of steroid hormones widely recognized for their potent anti-inflammatory and immunosuppressive effects. Among their many mechanisms of action, one of the most important involves the inhibition of phospholipase A2 (PLA2), an enzyme central to the inflammatory cascade. By inhibiting PLA2, glucocorticoids reduce the production of pro-inflammatory mediators such as prostaglandins and … Read more